Jessie, Bertram, and the Ross kids head to Bali, Indonesia for a family vacation, but when their private jet starts to fail, Jessie takes control of the cockpit and makes an emergency landing on a tropical island in the Pacific Ocean. Now, Jessie must figure out how to get the kids home safely, all while recovering from poisonous bug bites, escaping scary monsters, and tracking down Mr. Kipling.
- Debby Ryan as Jessie Prescott
- Peyton List as Emma Ross
- Cameron Boyce as Luke Ross
- Karan Brar as Ravi Ross
- Skai Jackson as Zuri Ross
- Kevin Chamberlin as Bertram Winkle
- This episode was part of Disney Channel's "Summer Adventure Weekend".
- This episode was promoted as the sequel to Take the A-Train... I Think?.
- Disney Channel promoted this episode under the title, "Lost in the Jungle". The episode Take The A-Train... I Think? was also promoted by Disney Channel as 'Lost in the City. Ironically, this episode was promoted as the sequel to that episode, which could be a reason why both episodes start with 'Lost in the...' (promotional titles).
- Bertram's hoarding obsession has been mentioned, although, he got rid of all of it.
- This is the second time a JESSIE episode aired on Friday the 13th. The first was Glue Dunnit: A Sticky Situation.
- The blue-breasted booby is a parody of the real animal, the blue-footed booby. The "breasted" part of the name is a reference to the word "booby" in the real animal's name. This is one of the few times that Disney has ever used dirty humor.
- Since Mr. Kipling revealed to be a female in The Secret Life of Mr. Kipling, it is probable that the "sweetheart" wild lizard in this episode was a boy.
- This is the first time Luke is seen in shorts and this is also the first episode to air in July.
- Bertram gave up wearing pants, but you can clearly see that his shorts are under the skirt.
- When Dr. Adams takes his fake claw out of the door, the hole is no longer visible in the next cut.